• Probiotics Blend (120 Billion CFU):
  L. acidophilus, L. brevis, L. buchneri, L. casei, L. crispatus, L. gasseri, L. lactis subsp. cremoris, L. delbrueckii subsp. bulgaricus, L. delbrueckii subsp. delbrueckii, L. delbrueckii subsp. lactis, L. fermentum, L. lactis subsp. lactis, L. helveticus, L. jensenii, L. johnsonii, L. kefiri, L. paracasei, L. plantarum, L. reuteri, L. rhamnosus, L. sakei, L. salivarius, L. curvatus, L. lactis subsp. diacetylactis, L. mesenteroides, B. infantis, B. adolescentis, B. animalis, B. bifidum, B. breve, B. lactis, B. longum, S. thermophilus, S. salivarius, P. pentosaceus, P. acidilactici.
• Organic Prebiotic Complex:
  Jerusalem Artichoke Root (Organic), Gum Arabic (Tree Exudate from Stem and Branches), Fibergum Bio, Chicory Root Powder (Cichorium intybus) (Organic).
• Digestive Enzyme Complex:
  Glucoamylase, Amylase, Chitosanase, Lipase, Protease, Maltase, Cellulase, Bromelain, Papain, Lactase.
• Fruit & Vegetable Complex:
  Strawberry, Carrot, Raspberry, Green Pea, Cherry, Red Bell Pepper, Plum.
• Urinary Tract Health Blend:
  D-Mannose Powder, Cranberry Juice Powder, Hibiscus Flower Extract, Dandelion Root Extract.

This unique combination ensures you get a comprehensive, all-around solution for digestive wellness.

• Support gut health by balancing your digestive system.
• Promote nutrient absorption to ensure your body gets the most from your meals.
• Optimize digestive function, keeping you feeling light and energized.
• Increase energy levels naturally, supporting a vibrant, active lifestyle.
  
  Feel better inside and out as you support your body’s digestive system!

To support a healthy gut and digestive system, simply take 1 softgel capsule ofBiome Renew Probioticsdaily with a meal. Easy to incorporate into your routine, it’s designed to be effective and convenient for long-term digestive health. Support your gut, improve nutrient absorption, and boost your energy—all with one simple step!

1. Probiotics & Plant-Based Compounds in Urinary Health

Saraiva, A., Raheem, D., Roy, P. R., & BinMowyna, M. N. (2025).
Probiotics and Plant-Based Foods as Preventive Agents of Urinary Tract Infection: A Narrative Review of Possible Mechanisms Related to Health.
Nutrients, 17(6), 986.

Key Findings:

• Reviews the role of specific probiotic strains in supporting urinary tract health
• Highlights plant-based synergists such as D-mannose and cranberry
• Supports their combined use as preventive agents against urinary tract infections (UTIs)
  

2. Non-Antibiotic Approaches to UTI Prevention

Cipriani, C., Carilli, M., Rizzo, M., & Miele, M. T. (2025).
Bioactive Compounds as Alternative Approaches for Preventing Urinary Tract Infections in the Era of Antibiotic Resistance.
Antibiotics, 14(2), 144.

Key Findings:

• Identifies D-mannose, cranberry, and probiotics as effective non-antibiotic strategies
• Emphasizes their importance amid rising antibiotic resistance
• Supports integrative, nutraceutical-based urinary health solutions
  

3. Synergistic Nutraceuticals for Urinary Support

Mainini, G., Passaro, M., & Schiattarella, A. (2020).
Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon, and Lactobacillus acidophilus.
Menopause Review, 19(1), 1–6.

Key Findings:

• Demonstrates the effectiveness of D-mannose, inulin (prebiotic), cranberry, and probiotics
• Validates the synergistic approach for urinary tract support
• Confirms benefits in reducing cystitis-related symptoms
  

4. Gut Microbiota, Inflammation & Metabolic Health (Incomplete Reference)

Dewulf, E. M., Cani, P. D.
Reference incomplete – full citation pending.

Notes:

• Research by these authors commonly focuses on gut microbiota modulation, inflammation, and metabolic health
• Relevant to probiotic-driven gut and immune system support
• Full citation can be added once source details are available
  

Scientific Disclaimer (Optional – Shopify Safe)

Hill, C., Guarner, F., Reid, G., et al. (2014). The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology.

Sanders, M. E., et al. (2019). Probiotics and prebiotics in intestinal health and disease. Nature Reviews Gastroenterology & Hepatology.

Ouwehand, A. C., Salminen, S., & Isolauri, E. (2002). Probiotics: An overview of beneficial effects. Antonie van Leeuwenhoek.

McFarland, L. V. (2015). From yaks to yogurt: The history, development, and current use of probiotics. Clinical Infectious Diseases.

Hemarajata, P., & Versalovic, J. (2013). Effects of probiotics on gut microbiota. Therapeutic Advances in Gastroenterology.

Ford, A. C., et al. (2014). Efficacy of probiotics in irritable bowel syndrome: systematic review and meta-analysis. American Journal of Gastroenterology.

Didari, T., et al. (2015). Effectiveness of probiotics in irritable bowel syndrome. World Journal of Gastroenterology.

Marco, M. L., et al. (2017). Health benefits of fermented foods. Current Opinion in Biotechnology.

Ritchie, M. L., & Romanuk, T. N. (2012). Meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS ONE.

Derrien, M., & van Hylckama Vlieg, J. E. (2015). Fate and impact of ingested bacteria within the gut microbiota. Trends in Microbiology.

Gibson, G. R., et al. (2017). Definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology.

Roberfroid, M. B. (2007). Prebiotics: the concept revisited. Journal of Nutrition.

Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients.

Kolida, S., & Gibson, G. (2011). Synbiotics in health and disease. Annual Review of Food Science and Technology.

Markowiak, P., & Śliżewska, K. (2017). Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients.

Reid, G., et al. (2003). Oral probiotics can resolve urogenital infections. FEMS Immunology & Medical Microbiology.

Stapleton, A. E. (2016). The vaginal microbiota and urinary tract infection. Microbiology Spectrum.

Kranjčec, B., et al. (2014). D-mannose powder for prophylaxis of recurrent urinary tract infections. World Journal of Urology.

Foxman, B. (2010). The epidemiology of urinary tract infection. Nature Reviews Urology.

Roxas, M., & Jurenka, J. (2007). Cranberry for prevention of urinary tract infections. Alternative Medicine Review.

Howell, A. B., et al. (2010). Cranberry proanthocyanidins and prevention of bacterial adhesion. Phytochemistry.

Guarner, F., & Malagelada, J. R. (2003). Gut flora in health and disease. The Lancet.

O’Toole, P. W., & Cooney, J. C. (2008). Probiotic bacteria influence the composition of the intestinal microbiota. Current Opinion in Biotechnology.

Qin, J., et al. (2010). A human gut microbial gene catalogue. Nature.

Turnbaugh, P. J., et al. (2007). The human microbiome project. Nature.

Vitetta, L., et al. (2014). Probiotics, prebiotics and gastrointestinal health. Gastroenterology Research and Practice.

Marteau, P., et al. (2001). Protection from gastrointestinal diseases by probiotics. American Journal of Clinical Nutrition.

Gill, H. S., & Guarner, F. (2004). Probiotics and human health. British Journal of Nutrition.

Bengmark, S. (2013). Gut microbiota and immune system. Clinical Nutrition.

Calder, P. C., et al. (2017). Diet, immunity, and the microbiome. Nutrients.

Azcarate-Peril, M. A., & Sikes, M. L. (2019). Short-chain fatty acids and gut health. Nutrients.

Tan, J., et al. (2014). Short-chain fatty acids and metabolic health. Advances in Immunology.

Louis, P., & Flint, H. (2017). Formation of propionate and butyrate by the gut microbiota. Environmental Microbiology.

Flint, H., et al. (2012). Microbial degradation of complex carbohydrates in the gut. Gut Microbes.

Di Pierro, F., et al. (2016). Digestive enzyme supplementation in gastrointestinal disorders. Journal of Clinical Gastroenterology.

Ianiro, G., et al. (2016). Digestive enzyme supplementation and digestive function. Digestive Diseases.

Whitcomb, D. C., & Lowe, M. E. (2007). Human pancreatic digestive enzymes. Digestive Diseases and Sciences.

Layer, P., et al. (2010). Enzyme supplementation and digestion. Best Practice & Research Clinical Gastroenterology.

Szajewska, H., et al. (2015). Probiotics for gastrointestinal disorders. Journal of Pediatric Gastroenterology and Nutrition.

Szajewska, H., & Kolodziej, M. (2015). Systematic review of probiotics for gastrointestinal disorders. Clinical Nutrition.

Hempel, S., et al. (2012). Probiotics for prevention of antibiotic-associated diarrhea. JAMA.

Goldenberg, J. Z., et al. (2017). Probiotics for the prevention of Clostridium difficile infection. Cochrane Database.

Allen, S. J., et al. (2010). Probiotics for treating acute infectious diarrhea. Cochrane Database.

Suez, J., et al. (2019). Personalized microbiome-based nutrition. Cell.

Lynch, S. V., & Pedersen, O. (2016). The human intestinal microbiome in health and disease. New England Journal of Medicine.

Belkaid, Y., & Hand, T. (2014). Role of the microbiota in immunity. Cell.

Honda, K., & Littman, D. (2016). The microbiota in adaptive immune homeostasis. Nature.

Thaiss, C., et al. (2016). Microbiota and host metabolism. Nature.

Tilg, H., & Moschen, A. (2015). Microbiota and metabolic disease. Gut.

Kho, Z. Y., & Lal, S. K. (2018). The human gut microbiome – a potential controller of wellness. Journal of Infection and Public Health.

• Black Walnut (Juglans nigra) Extract
• Wormwood (Artemisia absinthium) Extract
• Clove Buds (Syzygium aromaticum) Extract
• Oregano (Origanum vulgare Leaf) Extract
• Soursop (Annona muricata) Extract (Fruit)
• Turmeric (Curcuma longa) Root
• Pumpkin (Cucurbita pepo Seed) Extract
• Berberine HCl (Berberis aristata) Root
• Black Pepper (Piper nigrum) Fruit

✨ Note: Daily Value (DV) not established.

• Supports digestive health by promoting healthy gut flora.
• Assists in cleansing and detoxifying the body.
  
• Supports immune system health.
  
• Helps balance intestinal function and maintain digestive harmony.

Take 10-15 drops of the Black Walnut Wormwood Tincture in a glass of water, 1-3 times daily, or as directed by your healthcare professional. Shake well before use.

1. Black Walnut (Juglans nigra)

Omar, M. E. E. et al. (2020).
Anthelmintic effects of Juglans nigra on gastrointestinal parasites in sheep.

Jang, H. J. et al. (2005).
Cytotoxic constituents of black walnut and their potential antimicrobial activity.

Gutiérrez, R. M. et al. (2013).
Biological activities of Juglans species: traditional uses and phytochemical profile.

Key Findings:

• Demonstrates anti-parasitic (anthelmintic) properties
• Exhibits potential antimicrobial effects
• Supports traditional use for microbial balance
  

2. Wormwood (Artemisia absinthium)

Zafar, R. et al. (2022).
Antimicrobial activity of Artemisia absinthium essential oil against drug-resistant pathogens.

Mikulska, K. et al. (2010).
Use of Artemisia absinthium in parasitic infections: in vivo and in vitro evaluations.

Alnamer, R. et al. (2017).
Wormwood as a therapeutic plant: pharmacological effects and safety profile.

Key Findings:

• Shows antimicrobial and antiparasitic activity
• Supports gut microbial balance
• Validates therapeutic use and safety
  

3. Clove (Syzygium aromaticum)

Gul, P. et al. (2021).
Anthelmintic and antifungal potential of clove essential oil.

Chaieb, K. et al. (2007).
Eugenol as the active component in clove showing antimicrobial effects.

Kose, D. et al. (2019).
Synergistic antifungal activity of clove oil with antifungal drugs.

Key Findings:

• Exhibits antifungal and anti-parasitic activity
• Eugenol identified as a potent antimicrobial compound
• Synergistic effects with other antimicrobial agents
  

4. Garlic (Allium sativum)

Ankri, S. & Mirelman, D. (1999).
Broad-spectrum antimicrobial properties of allicin from garlic.

Amagase, H. et al. (2001).
Review of garlic's medicinal properties and clinical implications.

Key Findings:

• Provides broad-spectrum antimicrobial activity
• Supports gut microbial balance and digestive wellness
• Clinically studied for traditional and modern digestive support

Ahmad, A., et al. (2010). A review of antimicrobial properties of clove essential oil. Journal of Applied Microbiology.

Ali, B., et al. (2015). Essential oils used in aromatherapy: A systematic review. Asian Pacific Journal of Tropical Biomedicine.

Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and Infection.

Bakkali, F., et al. (2008). Biological effects of essential oils. Food and Chemical Toxicology.

Barnes, J., et al. (2007). Herbal Medicines, 3rd Edition. Pharmaceutical Press.

Bassolé, I.H.N., & Juliani, H.R. (2012). Essential oils in combination and their antimicrobial properties. Molecules.

Bilia, A.R., et al. (2002). Essential oils and antimicrobial activity. Journal of Ethnopharmacology.

Burt, S. (2004). Essential oils: their antibacterial properties and potential applications in foods. International Journal of Food Microbiology.

Cai, Y., et al. (2004). Antioxidant activity of plant extracts. Life Sciences.

Calzada, F., et al. (2003). Antiprotozoal activity of medicinal plants. Journal of Ethnopharmacology.

Cowan, M.M. (1999). Plant products as antimicrobial agents. Clinical Microbiology Reviews.

de Sousa, D.P. (2011). Analgesic-like activity of essential oils. Molecules.

Dorman, H.J.D., & Deans, S.G. (2000). Antimicrobial agents from plants. Journal of Applied Microbiology.

Efferth, T., et al. (2007). Molecular mechanisms of action of artemisinin. Current Drug Targets.

Ernst, E. (2000). Herbal medicine: balancing benefits and risks. British Journal of Clinical Pharmacology.

Feng, W., et al. (2020). Berberine in gastrointestinal diseases. Biomedicine & Pharmacotherapy.

Friedman, M., et al. (2002). Antibacterial activities of plant essential oils. Journal of Agricultural and Food Chemistry.

Gibbons, S. (2004). Anti-staphylococcal plant natural products. Natural Product Reports.

Gilling, D.H., et al. (2014). Antimicrobial effects of oregano oil. Frontiers in Microbiology.

Guo, Y., et al. (2015). Curcumin and gut health. Journal of Nutritional Biochemistry.

Hajhashemi, V., et al. (2003). Antioxidant activity of medicinal plants. Phytotherapy Research.

Han, J., et al. (2011). Berberine and gut microbiota. Journal of Translational Medicine.

Haukland, H.H., et al. (2010). Antimicrobial effects of herbal compounds. Phytomedicine.

Huang, W., et al. (2018). Anti-inflammatory effects of curcumin. Pharmacological Research.

Isman, M.B. (2000). Plant essential oils for pest and parasite control. Crop Protection.

Kamatou, G.P.P., et al. (2012). Biological activities of clove oil. Molecules.

Kong, W.J., et al. (2008). Berberine and intestinal microbiota. Nature Medicine.

Langeveld, W.T., et al. (2014). Essential oils as antimicrobial agents. Journal of Applied Microbiology.

Li, Y., et al. (2014). Berberine and metabolic regulation. Evidence-Based Complementary and Alternative Medicine.

Marchese, A., et al. (2016). Antimicrobial activity of essential oils. Molecules.

McKay, D.L., & Blumberg, J.B. (2006). A review of oregano tea. Phytotherapy Research.

Nostro, A., et al. (2004). Antimicrobial activity of oregano oil. Letters in Applied Microbiology.

O’Mahony, L., et al. (2005). Commensal bacteria and immune modulation. Gut.

Pandey, A.K., et al. (2017). Essential oils as antimicrobial agents. Frontiers in Microbiology.

Peterson, C.T., et al. (2018). Turmeric and gut microbiome. Journal of Evidence-Based Complementary & Alternative Medicine.

Prabuseenivasan, S., et al. (2006). Antibacterial activity of plant essential oils. BMC Complementary and Alternative Medicine.

Raut, J.S., & Karuppayil, S.M. (2014). Antifungal properties of essential oils. Industrial Crops and Products.

Ríos, J.L., & Recio, M.C. (2005). Medicinal plants and antimicrobial activity. Journal of Ethnopharmacology.

Salehi, B., et al. (2019). Antioxidant activity of plant-derived compounds. Biomolecules.

Sharifi-Rad, J., et al. (2017). Biological activities of medicinal plants. Phytotherapy Research.

Shreaz, S., et al. (2016). Essential oils and antimicrobial activity. Frontiers in Microbiology.

Singh, G., et al. (2005). Chemical composition and antimicrobial activity of essential oils. Food and Chemical Toxicology.

Soković, M., et al. (2010). Antifungal properties of plant extracts. Molecules.

Tapsell, L.C., et al. (2006). Health benefits of herbs and spices. Medical Journal of Australia.

Ultee, A., et al. (2002). Mechanisms of antimicrobial activity of carvacrol. Applied and Environmental Microbiology.

Vuddhakul, V., et al. (2007). Antimicrobial activity of herbs and spices. Food Control.

Wink, M. (2012). Modes of action of herbal medicines. Phytochemistry Reviews.

Yadav, V., et al. (2018). Plant-derived compounds and antimicrobial effects. Frontiers in Microbiology.

Zeng, H., et al. (2015). Curcumin and inflammation. Molecular Nutrition & Food Research.

Zhang, Y., et al. (2012). Berberine and intestinal health. International Journal of Molecular Sciences.